Well, I am always getting into different bands and music, and then sometimes my new interests push away old interests... I have a ton of old CD's I never listen to anymore (EBM, top-40 rock CD's, hair-metal, early-industrial albums like Throbbing Gristle, Einsturzende Neubauten, cheesy metal like White Zombie, etc)
And I currently listen to music I thought I'd never like when I was younger like punk, hardcore metal, psy/hard techno
(went thru a bunch of different phases when teenager, first grunge rock, then goth, Neu-hippie, then punk and now a sort of metalhead-punk-rocker... Had an identity crisis for a long time hahaha)
My taste in drugs hasn't changed much though, aside from slowing down (big time) in usage... LSD, MDMA, THC, Psilocybin, Caffeine, and a good old friend named Ethyl-alcohol!