Subtractor is a really basic softsynth, I dropped Reason a little while back because your only analog synths are Subtractor and Maelstrom. I know lots of people coax brilliant sounds out of it, but its only software, there should be at least 10 unique sounding analogy synths in Reason. And you have to manually patch effects in. You don't get to select a patch, hit a key and go *wow*
Hardware rules in that you get hundreds of sounds all instantly available. If that's good for you (it sure is for me), then get hardware once you have researched and know what you're getting. But it doesn't sound better. Your artistry in making things work together makes the music sound better.
You can do everything in software and midi controllers, it appears that most people do these days. Neither option is clearly better. What's clearly better for me is that hardware's workflow makes more sense to me. And I make more music and with less effort than on a computer.
Live